William A. Kinney, PhD

TRAINING

(1984) Ph.D. Ohio State University

RESEARCH OVERVIEW

Research interest: Natural product discovery using traditional and genomic methods.  Lead optimization of candidates for treating hepatitis B virus (HBV) and other filoviruses.
Research staff: Working closely with Profs. Yanming Du, Jason Clement, Michael Goetz, and John Kulp; and other faculty at the Blumberg Institute.

RESEARCH SUMMARY

Drug discovery and development of drugs for management of hepatitis B virus (HBV) and other diseases of unmet need.

SELECTED PUBLICATIONS:

“Nonpeptide Urotensin-II Receptor Antagonists: A New Ligand Class Based on Piperazino-Phthalimide and Piperazino-Isoindolinone Subunits” E. C. Lawson, D. K. Luci, S. Ghosh, W. A. Kinney, C. H. Reynolds, J. Qi, C. E. Smith, Y. Wang, L. K. Minor, B. J. Haertlein, T. J. Parry, B. P. Damiano, B. E. Maryanoff, J. Med. Chem. 2009, 52, 7432–7445.

“Generation of Novel, Potent Urotensin-II Receptor Antagonists by Alkylation–Cyclization of Isoindolinone C3-Carbanions” D. K. Luci, E. C. Lawson, S. Ghosh, W. A. Kinney, C. E. Smith, J. Qi, Y. Wang, L. K. Minor, B. E. Maryanoff, Tetrahedron Lett. 2009, 50, 4958-4961.

“Thrombogenic Collagen-Mimetic Peptides: Self-Assembly of Triple Helix-Based Fibrils Driven by Hydrophobic Interactions” M. A. Cejas, W. A. Kinney, C. Chen, J. G. Vinter, H. R. Almond, Jr., K. M. Balss, C. A. Maryanoff, U. Schmidt, M. Breslav, A.Mahan, E. Lacy, C. Yang, B. E. Maryanoff,  Proc. Natl. Acad. Sci. USA 2008, 105, 8525-8530.

“Suzuki–Miyaura Approach to JNJ-26076713, an Orally Active Tetrahydroquinoline-Containing Alpha-V Beta-3/Alpha-V Beta-5 Integrin Antagonist.  Enantioselective Synthesis and Stereochemical Studies” W. A. Kinney, C. A. Teleha, A. S. Thompson, M. Newport, R. Hansen, S. Ballentine, S. Ghosh, A. Mahan, G. Grasa, A. Zanotti-Gerosa, J. Dingenen, C. Schubert, Y. Zhou, G. C. Leo, D. F. McComsey, R. J. Santulli, B. E. Maryanoff , J. Org. Chem. 2008, 73, 2302-2310.

“Studies with an Orally Bioavailable Alpha-V Beta-3/Alpha-V Beta-5 Integrin Antagonist in Animal Models of Ocular Vasculopathy: Retinal Neovascularization in Mice and Retinal Vascular Permeability in Diabetic Rats” R. J. Santulli, W. A. Kinney, S. Ghosh, B. L. DeCorte, L. Liu, R. W. A. Tuman, Z. Zhou, N. Huebert, S. E. Bursell, A. C. Clermont, M. B. Grant, L. C. Shaw, S. A. Mousa, R. A. Galemmo, Jr., D. L. Johnson, B. E. Maryanoff, B. P. Damiano, J. Pharmacol. Exp. Ther. 2008, 324, 894-901.

“Nanoparticles That Display Short Collagen-Related Peptides. Potent Stimulation of Human Platelet Aggregation by Triple Helical Motifs” M. A. Cejas, C. Chen, W. A. Kinney, B. E. Maryanoff, Bioconjugate Chem. 2007, 18, 1025-1027.

“Collagen-Related Peptides: Self-Assembly of Short, Single Strands into a Functional Biomaterial of Micrometer Scale” M. A. Cejas, W. A. Kinney, C. Chen, G. C. Leo, B. A. Tounge, J. G. Vinter, P. P. Joshi, and B. E. Maryanoff, J. Am. Chem. Soc. 2007, 129, 2202-2203.

“Structure-Function Analysis of Urotensin II and Its Use in the Construction of a Ligand-Receptor Working Model” W. A. Kinney, H. R. Almond, Jr., J. Qi, C. E. Smith, R. J. Santulli, L. de Garavilla, P. Andrade-Gordon, D. S. Cho, A. M. Everson, M. A. Feinstein, P. A. Leung, B. E. Maryanoff, Angewandte Chemie, Int. Ed. 2002, 41, 2940-2944.

“A Spermine-Coupled Cholesterol Metabolite from the Shark with Potent Appetite Suppressant and Antidiabetic Properties” M. Zasloff, J. I. Williams, Q. Chen, M. Anderson, T. Maeder, K. Holroyd, S. Jones, W. A. Kinney, K. R. Cheshire, Int. J. Obesity 2001, 25, 689-697.

“A Short Formal Synthesis of Squalamine from a Microbial Metabolite” W. A. Kinney, X. Zhang, J. I. Williams, S. Johnston, R. S. Michalak, M. Deshpande, L. Dostal, J. P. N. Rosazza, Org. Lett. 2000, 2 (19), 2921-2922.

“Aminosterols from the Dogfish Shark Squalus acanthias” M. R. Rao, A. E. Shinnar, L. A. Noecker, T. L. Chao, B. Feibush, B. Snyder, I. Sharkansky, A. Sarkahian, X. Zhang, S. R. Jones, W. A. Kinney, M. Zasloff, J. Nat. Products 2000, 63 (5), 631-635.

“Synthesis of Squalamine Utilizing a Readily Accessible Spermidine Equivalent” X. Zhang, M. N. Rao, S. R. Jones, B. Shao, P. Feibush, M. McGuigan, N. Tzodikov, B. Feibush, I. Sharkansky, B. Snyder, L. M. Mallis, A. Sarkahian, S. Wilder, J. E. Turse, W. A. Kinney, H. J. Kjaersgaard, R. S. Michalak, J. Org. Chem. 1998, 63, 8599-8603.

“Squalamine Inhibits Angiogenesis and Solid Tumor Growth in Vivo and Perturbs Embryonic Vasculature”  A. K. Sills, Jr., J. I. Williams, B. M. Tyler, D. S. Epstein, E. P. Sipos, M. P. McLane, S. Pitchford, K. Cheshire, F. H. Gannon, W. A. Kinney, T. L. Chao, J. D. Davis, M. Donowitz, J. Laterra, M. Zasloff, H. Brem, Cancer Research 1998, 58, 2784-2792.

“Design and Synthesis of [2-(8,9-Dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]-phosphonic Acid (EAA-090), a Potent N-Methyl-D-aspartate Antagonist, via the Use of 3-Cyclobutene-1,2-dione as an Achiral Alpha-Amino Acid Bioisostere”  W. A. Kinney, M. Abou-Gharbia, D. T. Garrison, J. Schmid, D. M. Kowal, D. R. Bramlett, T. L. Miller, R. P. Tasse, M. M. Zaleska, J. A. Moyer, J. Med. Chem. 1998, 41, 236-246.

“A General Approach to Annulated 4-Cyclooctenones by Aliphatic Claisen Rearrangement. Stereospecific Total Synthesis of Precapnelladiene” W. A. Kinney, M. J. Coghlan, L. A. Paquette, J. Am. Chem. Soc. 1985, 107, 7352.